- Title
- Independent and interactive influences of environmental UVR, vitamin D levels, and folate variant MTHFD1-RS2236225 on homocysteine levels
- Creator
- Jones, Patrice; Lucock, Mark; Martin, Charlotte; Thota, Rohith; Garg, Manohar; Yates, Zoe; Scarlett, Christopher J.; Veysey, Martin; Beckett, Emma
- Relation
- ARC.G0188386
- Relation
- Nutrients Vol. 12, Issue 5, no. 1455
- Publisher Link
- http://dx.doi.org/10.3390/nu12051455
- Publisher
- MDPI AG
- Resource Type
- journal article
- Date
- 2020
- Description
- Elevated homocysteine (Hcy) levels are a risk factor for vascular diseases. Recently, increases in ultraviolet radiation (UVR) have been linked to decreased Hcy levels. This relationship may be mediated by the status of UVR-responsive vitamins, vitamin D and folate, and/or genetic variants influencing their levels; however, this has yet to be examined. Therefore, the independent and interactive influences of environmental UVR, vitamin D and folate levels and related genetic variants on Hcy levels were examined in an elderly Australian cohort (n = 619). Red blood cell folate, 25-hydroxyvitamin D (25(OH)D), and plasma Hcy levels were determined, and genotyping for 21 folate and vitamin D-related variants was performed. Erythemal dose rate accumulated over six-weeks (6W-EDR) and four-months (4M-EDR) prior to clinics were calculated as a measure of environmental UVR. Multivariate analyses found interactions between 6W-EDR and 25(OH)D levels (pinteraction = 0.002), and 4M-EDR and MTHFD1-rs2236225 (pinteraction = 0.006) in predicting Hcy levels. The association between 6W-EDR and Hcy levels was found only in subjects within lower 25(OH)D quartiles (<33.26 ng/mL), with the association between 4M-EDR and Hcy occurring only in subjects carrying the MTHFD1-rs2236225 variant. 4M-EDR, 6W-EDR, and MTHFD1-rs2236225 were also independent predictors of Hcy. Findings highlight nutrient-environment and gene-environment interactions that could influence the risk of Hcy-related outcomes.
- Subject
- homocysteine; folate; vitamin D; ultraviolet radiation; genetic variant
- Identifier
- http://hdl.handle.net/1959.13/1422107
- Identifier
- uon:37802
- Identifier
- ISSN:2072-6643
- Rights
- © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
- Language
- eng
- Full Text
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